Colon cancer has a high rate of recurrence even with good response to modern therapies.Novel curative adjuncts are needed.Oncolytic viral therapy has shown preclinical promise against colon cancer but lacks robust efficacy in clinical trials and Sinus raises regulatory concerns without real-time tracking of viral replication.Novel potent vectors ar
Introduction: The Euchromatic Histone Methyl Transferase Protein 2 (EHMT2), also known as G9a, deposits transcriptionally repressive chromatin marks that play pivotal roles in the maturation and homeostasis of multiple organs.Recently, we have shown that Ehmt2 Grape Seed Extract inactivation in the mouse pancreas alters growth and immune gene expre
We have previously demonstrated that subsets of Ssn6/Tup target genes have distinct requirements for the Schizosaccharomyces pombe homologs of the Tup1/Groucho/TLE co-repressor proteins, Tup11 and Tup12.The very high Pizza Tray level of divergence in the histone interacting repression domains of the two proteins suggested that determinants distingu
The migrations of the new millennium are economic, but also social and political migrations.In Italy this phenomenon has taken on a significant dimension, both for the number of migrants who land on the coasts and for the territories affected by the emergency.Today, it is not possible to handle the emergency in landing areas; local institutions and
Acute respiratory distress syndrome (ARDS), associated with high mortality rate, affects up to 67% of hospitalized COVID-19 patients.Early evidence indicated that the pathogenesis of COVID-19 evoked ARDS is, at least partially, mediated by hyperinflammatory cytokine storm in which interleukin 6 (IL-6) plays an essential role.The corticosteroid dexa